For example, increased CXCR2 signalling reportedly underpins oncogenic Ras-induced senescence in p53 wild-type tumour cells (Acosta et al, 2008), but the effects of oncogenic Ras-induced CXC-chemokine signalling may have different effects, for example, in cells harbouring abnormal p53 function. Here, TP53 is linked to neoplasm.