Previous studies that have characterized CXCL8 expression in CRC tissue have often been conducted in a more advanced disease stage and used techniques other than immunohistochemistry (Ueda et al, 1994; Chung and Chang, 2003; Csiszar et al, 2004; Erreni et al, 2009), however, almost two-thirds of our cohort comprised stage II CRC. This evidence concerns the gene CXCL8 and colorectal carcinoma.