IL10 and infection: However, one likely hypothesis to explain our findings is that the lack of hygiene can lead a greater exposition to weakly pathogenic organisms, which can activate a regulatory network characterized by the up-regulation of Treg cells and increased production of IL-10 [33,34], which can be associated to infections with low parasite loads such as with A. lumbricoides and T. trichuris, which have been previously described infecting the studied population, as mentioned above [32].