The immunization with a conjugated multiple-antigen peptide (cyclic closed chain dodecapeptide, cDDR5-MAP) induced long-lasting anti-cDDR5 antibodies reacting with both human and macaque CCR5 molecules, which suppressed in vitro infections by an R5-HIV-1 laboratory isolate, by R5-HIV-1 primary isolates belonging to clade A and C and by a pathogenic SHIV isolate. The gene discussed is CCR5; the disease is infection.