In this example, SemRep, which integrates MetaMap [14] concept mapping functionality, has determined that "IGF1R gene" and "Carcinoma of bladder" are the respective subject and object arguments in the original text by mapping the original sentence's terms to preferred concepts in the Unified Medical Language System (UMLS) [15] Metathesaurus. The gene discussed is IGF1R; the disease is urinary bladder carcinoma.