Thus, in the lung and kidney fibrosis models, endogenous TGF-β and CTGF were induced [28], and in the CTGF and TGF-β synergy model, recombinant exogenous TGF-β and CTGF were coadministered directly, with the latter approach resulting in profound encapsulating peritoneal sclerosis and systemic multiorgan fibrosis. This evidence concerns the gene CCN2 and fibrosis.