Moreover, adiponectin treatment of CAD and nonCAD cells significantly induced IL-10 (13.8-fold, p = 0.005 and 19-fold, p < 0.001, respectively), although adiponectin-induced IL-10 release was significantly lower in CAD patients compared to nonCAD subjects (69.2 ± 80.1 pg/ml vs. 386.3 ± 488.2 pg/ml, p = 0.047) (Figure 5). This evidence concerns the gene IL10 and coronary artery disorder.