In stepwise multivariable analysis with age, gender, waist to hip ratio, the presence of CAD, Matsuda index and the various medications as independent variables, insulin sensitivity (Matsuda index) (beta ± SE: 0.43 ± 0.02, p = 0.024) was the sole independent determinant of adiponectin levels (R2 = 0.10). This evidence concerns the gene INS and coronary artery disorder.