Therefore, we conclude that IM-1.6.α may be a possible vaccine candidate against TB, based on its uniqueness of utilizing novel antigens (secreted within the natural environment of the macrophages which may be of paramount importance for evoking protection) and presence of IL-1+IL-6+TNF-α (for induction and sustenance of enduring CD4 and CD8 T cell memory responses). Here, TNF is linked to tuberculosis.