As Protein Kinase C (PKC) is the enzyme responsible for initiation of oxidative mechanisms in macrophages, which play an important role in the development of protective immunity [26], the inhibition of protein kinase C (PKC) gene in the liver of mice infected with E. multilocularis at 3 months (Table S2) may suggest one possible mechanism used by E. multilocularis to evade the host immune response, as was observed in Leishmania spp[26] and T. congolense[27] infections. Here, PRRT2 is linked to infection.