BRAF and Skin rash: As far as TTP was concerned, the univariate analysis (Table 3 and 4) demonstrated significant associations with: i) KRAS mutations (p = 0.001); ii) BRAF mutations (p = 0.001); iii) AREG mRNA expression (p = 0.018); iv) EREG mRNA expression (p = 0.002) and v) the development of moderate severe skin rash (p<0.0001).