months, p = 0.102, respectively) (Figure 4A and 4B); similarly, there was no difference in terms of median OS between patients with PIK3CA mutant (13.6 months) and wt (15.0 months) primary tumours (p = 0.44; Figure 5A), as well as between patients with lost (14.3 months) or normal (15.1 months) PTEN function (p = 0.82; Figure 5B). This evidence concerns the gene PIK3CA and neoplasm.