PIK3CA and neoplasm: TTP and OS were significantly lower among patients whose tumours carried KRAS mutations (3.1 vs. 6.4 months, p = 0.001 and 10.6 vs. 16.3 months, p = 0.026, respectively) (Figure 2A and 2B). Similarly, TTP and OS were significantly lower among patients whose tumours carried BRAF mutations (2.1 vs. 5.2 months, p = 0.001 and 4.3 vs. 15.1 months, p<0.0001, respectively) (Figure 3 and 4). There was no significant correlation in terms of TTP according to PIK3CA mutational status or PTEN expression in all treated patients (4.9 vs. 5.