Although recent studies have emphasized its role as an adipose hormone that mediates pro-inflammatory actions in various metabolic diseases like obesity, type 2 diabetes and cardiovascular disease [13], visfatin was originally identified as a pre-B cell colony enhancing factor (PBEF) and is thought to play roles in immune response and inflammation [14], [15], [16], [17]. Here, NAMPT is linked to obesity due to melanocortin 4 receptor deficiency.