Tumor hypoxia can activate the pSTAT3 immunosuppressive pathway thereby triggering the downstream synthesis of hypoxia inducible factor (HIF)-1α that can then induce regulatory T cells [10] and vascular endothelial growth factor (VEGF)[11], [12], which in addition to promoting angiogenesis is also immunosuppressive [13], [14]. The gene discussed is VEGFA; the disease is neoplasm.