There is low linkage disequilibrium between rs1044498) in ENPP1 and the two ENPP1 related variants investigated in the present study (r2<0.3 and D′<0.6 in Inter99).Because of the low impact on type 2 diabetes, and therefore presumably low impact on intermediary phenotypes for these ENPP1 intronic variants, we need larger well-characterised study populations to clarify their potential underlying metabolic influence. The gene discussed is ENPP1; the disease is type 2 diabetes mellitus.