The top ten type 2 diabetes variants included variants in eight genes: RAPGEF1 rs4740283, ENPP1 rs2021966 and rs858341, NRF1 rs1882095, TP53 rs1042522, SLC2A2 rs10513684 and rs5400, SLC2A4 rs222852, FOXC2 rs4843165, and PPARG. The gene discussed is FOXC2; the disease is type 2 diabetes mellitus.