Although hjv expression is not iron responsive[8], [11], iron deficiency induces production of soluble hjv[8], while iron loading inhibits release of soluble hemojuvelin.[12], [13] It has been proposed that soluble Hjv, produced via a Furin-mediated proteolysis of membrane-bound Hjv[13], [14], antagonizes the function of membrane-bound Hjv[12], [15] resulting in low levels of hepcidin expression. The gene discussed is HJV; the disease is nutritional disorder.