A study of tyrosine phosphorylation of c-MET in a renal carcinoma cell line suggested that c-MET (pY1349) phosphorylation occurs 5 minutes after HGF treatment and persists for 120 minutes while c-MET (pY1234/1235) phosphorylation occurs 30 minutes after HGF treatment and is subject to rapid turnover [31]. This evidence concerns the gene HGF and renal carcinoma.