SHH and omphalocele: Introducing a Shh mutation could restoresome of these phenotypes in Gli3Xt/+; Alx4Lst/Lstembryos (Fig. 3H–J).The omphalocele observed in Gli3Xt/+; Alx4Lst/Lstembryos (Fig. 3E) wasrestored completely in Gli3Xt/+; Alx4Lst/Lst;Shh+/− embryos (Fig.3H).