Figure 3B confirms active infection of Hp within 2 weeks and that curcumin or TT completely eliminated Hp from mouse stomach. These data indicate that even a dose of 25 mg/kg of curcumin was equipotent to the human dose of TT in eradicating Hp in vivo. The activities of secreted MMP-3 and -9 (Figure 3C and D) that escalated significantly due to Hp-infection was reduced dose dependently by curcumin treatment and reduced to control level by either 25 or 50 mg/kg b.w. while the TT treatment diminished the activity by only 50% at either doses used (Figure 3E and F). Here, MMP3 is linked to infection.