When comparing the top 30 most over- and under-expressed genes in AD across the 3 brain samples (Tables S1, S2, S3), DHX58 (DEXH box polypeptide 58) and STAB1 (Stabilin 1) are up-regulated in both total brain (2.13 fold change (FC), p = 0.01 and 4.9 FC, p = 0.01, respectively) and frontal lobe (3.96 FC, p = 0.03 and 10.5, p<1×10−16, respectively), while TFR1 (transferrin receptor) is down-regulated in both regions (−50.92 FC, p = 3.8×10−8 and -17.15 FC, p = 9.2×10−5, respectively). This evidence concerns the gene DHX58 and Alzheimer disease.