Genes in the AD temporal lobe detected as down-regulated by both approaches include dopamine receptor 2 (DRD2), AMPA1 receptor (GRIA1), glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1), glutamate transporter EAAT3 (SLC1A1), a-synuclein (SCNA), high affinity BDNF/NT-3 receptor (TrkB), high affinity NT-3 receptor (TrkC), glutamic acid decarboxylase 1 (GAD1) and glutamic acid decarboxylase 2 (GAD2). This evidence concerns the gene BDNF and Alzheimer disease.