Using the same selection criteria, frontal and temporal lobe samples from the AD brain showed alternative promoter usage in eleven genes (ACAP3, ARGLU1, CHD3, KIF5A, LENG8, MAPK3, NR1D1, PDE1B, PIP5K2B, RPH3A, WDR47) and three genes (APOE, KIF5A, PP2R4), respectively. The gene discussed is PDE1B; the disease is Alzheimer disease.