Moreover, in PSC patient with cholangitis, prohepcidin levels correlated with CRP (r = 0.48, p = 0.03) and bilirubin serum levels (r = 0.71, p = 0.0002, Fig. 6B,C) thereby suggesting that prohepcidin levels in the bile reflect the extent of biliary infection. Here, CRP is linked to cholangitis.