However, a study implicating actin participation in targeting and/or maintenance of apical localization of ABC transporters involves knockout mice in which the radixin gene, encoding for the dominant ERM protein in the liver, was eliminated by targeted disruption [38]; hence, elimination of radixin, which is localized at the bile canalicular membrane, resulted in progressive dilation of canaliculi, decreased microvilli and most importantly jaundice, due to impaired apical trafficking of ABCC2 and disappearance of other characteristic canalicular ABC transporters. Here, ABCC2 is linked to Jaundice.