Further, in contrast to the leptin receptor-deficient Zucker rat, where obesity develops independently of circulating leptin [23], the diet-induced obese rat directly reflects common forms of human obesity, where leptin, insulin, glucose, triglycerides and blood pressure are elevated [1], [23], [24], [25], [26]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.