Virus is able to reach the central nervous system more quickly after vaginal infection in mice deficient in CXCL10, and trafficking of NK cells and HSV-specific CD8+ T-cells (but not CD4+ T-cells) to infected tissue is impaired in both CXCL9 and CXCL10-deficient mice [54]. This evidence concerns the gene CXCL10 and infective vaginitis.