To date, most data highlights LZAP as a tumor suppressor [2], [3], [4], [5], [7], but its role as a p38 regulator imply that LZAP could also have opposing cellular effects or that LZAP inhibition of p38 could be restricted to circumstances where inhibition of p38 suppresses tumor promoting activity. This evidence concerns the gene CDK5RAP3 and neoplasm.