In the SAM analysis, two miRNAs were upregulated: (a) miR-21, which is overexpressed in many kinds of cancers and accelerates cell migration and invasion thorough phosphatase and tensin homolog (PTEN) in HCC [26]; and (b) miR-34a, which is a component of the p53 tumor suppressor network. This evidence concerns the gene PTEN and hepatocellular carcinoma.