Conversely, for many other DUBs (USP31, USP39, USP48, PSMD14, USP1, PSMD7, STAMBP, USP16, USP24, COPS6, EIF3S5 and JOSD1) our findings represent, to the best of our knowledge, the first report of alterations in cancer. The gene discussed is USP24; the disease is cancer.