While a comprehensive discussion of the known functions of all the dysregulated DUBs identified in this study will be impossible here (see however Table S2 and [8], [18], [19] for recent reviews of the biochemical functions of DUBs implicated in cancer), we would like to briefly highlight some of the functional characteristics of the DUBs that were extensively validated in the present study (USP9X, UCHL1, USP1, USP10, USP11, and USP22). Here, USP22 is linked to cancer.