PI3K expression was significantly lower in both fibroadenoma and malignant compared to normal breast tissue (p<0.0005, p<0.0001 respectively, Figure 4c) with a negative correlation observed between NIS and PI3K (r = −0.21 p<0.05, n = 97, Figure 4d). The gene discussed is SLC5A5; the disease is Fibroadenoma.