HF-feeding impaired insulin-mediated glucose clearance in both control and AOiGHD mice (AUC, LF-controls 13819±635 vs. HF-controls 16391±808 [p<0.05] and LF-AOiGHD 12021±459 vs. HF-AOiGHD 14893±829 [p<0.05]). The gene discussed is INS; the disease is hydrops fetalis.