TNFRSF8 and neoplasm: Advantages of these nanocomplexes include: 1) incorporating siRNAs into a nano-sized carrier will increase their physical size and could prevent the rapid elimination of siRNA from the blood circulation in vivo; 2) incorporating CD30 aptamers will enable specific accumulation of the nanocomplexes within tumor sites and eliminate potential off target side effects of the nanocomplex components; and 3) it is possible to incorporate more than one siRNA and/or therapeutic drug into the nanocomplex to generate additive or synergistic repressive effects on tumor cells.