MLANA and melanoma: These results led to the following conclusions: 1) The MART-1- DC vaccine is safe and immunogenic; 2) MART-1-specific T cell responses are detected even at the lowest DC vaccine dose; 3) intradermal vaccination may be superior to intravenous administration; 4) in many patients the increase in circulating antigen-reactive cells is transient; and 5) complete clinical responses occurred in patients who developed T cell responses to additional class I and class II melanoma determinants (i.e., epitope spreading).