After genotyping 90 SLE patients and 94 healthy controls, Yen et al. [34] concluded that CYP1A1 4887A may be a precipitating factor for SLE, and they detected a synergistic effect for SLE susceptibility between CYP1A1 4887C/A and Mn SOD 1183T/T. This evidence concerns the gene SOD2 and systemic lupus erythematosus.