Treatment of MCF7 cells with mevastatin resulted in a 10-fold to 15-fold induction of HMG-CoAR activity in association with a 2.5-fold to 3.5-fold induction of HMG-CoA reductase mRNA expression [29], suggesting that treatment with statins may increase tumor-specific HMG-CoAR expression in vivo; however, this suggestion remains to be fully elucidated. The gene discussed is HMGCR; the disease is neoplasm.