LPL and Hypercholesterolemia: However, in diabetic state, lipoprotein lipase is not activated due to insulin deficiency, resulting in hypertriglyceridemia[23] and insulin deficiency is also associated with hypercholesterolemia due to metabolic abnormalities.[24] In our study also, the diabetic rats showed hypercholesterolemia and hypertriglyceridemia and the treatment with plant extract significantly decreased both cholesterol and triglyceride levels.