In patients with type 2 diabetes, salsalate in doses of 3 and 4,5 grams per day improved insulin resistance as measured during a hyperinsulinemic euglycemic clamp, fasting and post challenge glucose levels, decreased free fatty acid (FFA) levels and increased adiponectin levels by 35-45% without an effect on bodyweight[87]. The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.