ARBs also have anti-inflammatory effects as seen by lowering effect on plasma TNF-α and IL-6 levels in patients with diabetes and hypertension[120,122] Telmisartan, but not valsartan, was shown to attenuate TNF-α induced IL-6 production by vascular smooth muscle cells in a PPAR-γ dependent manner[123]. Here, TNF is linked to hypertensive disorder.