For example nebivolol (5 mg daily), which has β2 intrinsic sympaticomimetic action, increases plasma adiponectin levels in overweight patients with hypertension[94] Celiprolol (up to 400 mg daily), a combined β1 antagonist and β2 agonist reduces plasma leptin levels without a change in bodyweight in patients with dyslipidemia [95]. This evidence concerns the gene LEP and metabolic syndrome.