APOC3 and Insulin resistance: The goal of the present study was to elucidate the nature of the relationship between the liver TG content and insulin resistance through an examination of the metabolic sequelae of two sequence polymorphisms in APOC3 that were associated with the liver TG content in a previous study.13 Here we found that one of the variants (rs2854116) was weakly associated with HTGC (P = 0.041) but in the direction opposite to that of the previous report.13 Carriers for this variant had lower HTGC values than noncarriers.