Hepatic TG levels typically are low in lean, nondiabetic individuals, whereas approximately 50% of those with a body mass index (BMI) > 30 kg/m21 and approximately 75% of those with adult-onset type 2 diabetes have steatosis.3 Thus, although obesity and insulin resistance are important susceptibility factors for NAFLD, not all obese or insulin-resistant individuals develop hepatic steatosis. The gene discussed is INS; the disease is Insulin resistance.