PNPLA3 and fatty liver disease: The PNPLA3-I148M variant is most common in Hispanics [minor allele frequency (MAF) = 0.48], the group with the highest prevalence of hepatic steatosis (45%), and is least common in African Americans (MAF = 0.14), who have the lowest incidence of steatosis (24%); the frequency in Caucasians is intermediate (MAF = 0.23).