The two variants prevent insulin binding and thus increase the levels of APOC3 messenger RNA and protein.17 APOC3 is transported on circulating lipoproteins and limits clearance of TG-rich particles.18 Petersen et al.13 proposed that the sequence variants lead to increased uptake of chylomicron remnants by the liver, and this results in NAFLD and hepatic insulin resistance. Here, INS is linked to Insulin resistance.