The rs2854117 and rs2854116 variants were reported to be in linkage disequilibrium with a polymorphic SstI site in the 3′ untranslated region of APOC3 that was strongly associated with hypertriglyceridemia in several small studies.14, 27 In subsequent studies using larger samples, the association was inconsistent. This evidence concerns the gene APOC3 and hypertriglyceridemia.