DNE3 inhibited the motility (Figures 8(a) and 8(c)) and invasion (Figures 8(b) and 8(d)) of A2058 cell lines, and DNE3 clearly inhibited the secretion of MMP-2, MMP-9 (Figure 8(e)), and u-PA (Figure 8(f)), thus indicating that DNE3 might have anti-invasive properties against a broad spectrum of melanoma cells. This evidence concerns the gene MMP2 and melanoma.