ERBB2 and breast cancer: Furthermore, other confounding factors, like antigen degradation of archival formalin fixed, paraffin-embedded tissue blocks, should also be considered for the reportedly high frequency of hormone receptor negativity, with subsequently higher frequencies of both basal-like BC identified by the triple-negative CK+ profile (ER−/PgR−/Her-2/neu−/basal CK+) and unclassified triple-negative types [33, 36, 37, 54, 61].