In addition, while phosphoenolpyruvate carboxykinase (PEPCK) protein expression was unchanged (Figure 3(c)), both acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) protein expressions were reduced in T2D + AM-W rats (Figures 3(d) and 3(e)). Here, PCK2 is linked to type 2 diabetes mellitus.