TNF and Sepsis: Since these genes are form crosstalks in the pathogenesis of sepsis, we further studied the synergetic effects of 13 SNPs in 9 cytokines and found that polymorphisms of IL-1β/-1470, IL-1β/-511, IL-1β/-31, IL-4/-589, IL-6/-572, IL-8/-251, IL-10/-819, and TNFα/-308 are susceptibility loci for the development of sepsis and organ dysfunction in major trauma patients.