For example, although Wnt1 itself has not been implicated in human breast cancer, other members of this family as well as targets of the Wnt signaling pathway, such as β-catenin, E-cadherin, cyclin D1, etc., are known to be mutated or deregulated in a number of human cancers [67,68] and several Fgf family members have been implicated in human breast cancer [59,69]. This evidence concerns the gene CCND1 and breast cancer.