Age, sex, duration of the diabetes, glycemic control, blood pressure and genetic susceptibility are considered as risk factors which influence the development of early nephropathy in childhood type 1 diabetes.(1) Early detection of a rise in albumin excretion while still within the normal range would enable intervention to prevent the development of incipient nephropathy.(2, 3, 4) Therefore, annual screening of albumin excretion in urine for early detection of microalbuminuria (MA) is both necessary and useful, especially in children with diabetes of a duration greater than 10 years. The gene discussed is ALB; the disease is kidney disorder.