The aim of this study was to analyze (a) the relationship between the degree of obesity and serum adiponectin, TNF−α, leptin, insulin levels, lipid profile; (b) the relationship between insulin resistance/glucose tolerance and adipocytokine levels; and (c) the value of adipocytokine level as a marker of MS. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.