Mutations in the NROB1 gene are found in the dosage sensitive sex reversal adrenal hypoplasia congenita on the X−chromosome, in the gene 1 (DAX−1) lead to neonatal adrenal insufficiency and failure to undergo puberty with hypogonadotrophic hypogonadism (47, 48, 49, 50, 51). Here, NR0B1 is linked to hypogonadotropic hypogonadism.