NR3C2 and Pelger-Huet anomaly: Corticosterone, 18−hydroxycorticosterone and aldosterone are elevated through renin/angiotensin stimulation in disorders of aldosterone receptor and the gene NR3C2 encoding the mineralocorticoid receptor can have mutations in  some (pseudohypoaldosteronism − PHA) (94, 95, 96, 97).