We further examined the effect of EGCG on erbB2/Her2 employing HNSCC and breast cancer cell lines, and found that EGCG can inhibit the erbB2/Her2 activation, demonstrating the first example of erbB2/Her2 inhibition by EGCG in human malignancies [32]. The gene discussed is ERBB2; the disease is head and neck squamous cell carcinoma.