In addition, we confirmed that the inhibition of proliferation of the GL-1 cell line by lestaurtinib is most likely mediated via decreased levels of the STAT5 and ERK1/2 phosphoproteins, all of which reinforces the underlying conservation between dysregulated pathways in humans and canine leukemia, even across diseases (AML and ALL, respectively). The gene discussed is MAPK3; the disease is acute myeloid leukemia.