CTNNB1 and endometrial cancer: On one hand the molecular changes in two major subtypes of endometrial cancer are well known: the estrogen-related type I shows defects in DNA-mismatch repair, mutations in PTEN, beta-catenin, and k-ras, while type II, nonendometrioid such as papillary serous and clear cell shows aneuploidy and p53 mutations [6].