Acetylation of K5 and K16 was localized to the mantle zone whereas acetylation of K8 and K12 was localized to both the mantle zone and the germinal center (data not shown).The diversity of IBD and the difficulty in successfully distinguishing between Ulcerative colitis and Crohn's disease underlined the criteria for employing two different animal models for studying histone acetylation (TNBS and DSS) associated with Crohn's disease and Ulcerative colitis respectively [30]. This evidence concerns the gene KRT16 and ulcerative colitis.