TNFRSF1B and ocular melanoma: Thus the genes for Tnfa and its receptors Tnfr1a and Tnfr1b, Tnf9 and Tnfr9, as well as Tnf1r18 are up-regulated early in OM and decline after day 3, although Tnfa remained 1.8X up-regulated at day 5.