Tatsuguchi et al [48], on the other hand, found an increase in ghrelin immunoreactive cells following H pylori eradication in 50 patients with either peptic ulcer disease or gastritis, while in 11 patients who did not respond to eradication therapy, there was no difference in the number of ghrelin immunoreactive cells pre-and post-eradication therapy. Here, GHRL is linked to peptic ulcer disease.