Likewise, the presence of multiple genes on our list classified as effectors of the cytokine-cytokine receptor signaling, TGF-β, WNT, Hedgehog or MAP Kinase signaling pathways would support previous published studies suggesting that these particular signaling pathways are involved in the cross-talk that occurs between prostate stromal and prostate epithelial/cancer cells in development or disease [29]–[31]. This evidence concerns the gene TGFB1 and cancer.