Twelve PTEN +/+ and twelve PTEN −/− glioma-bearing mice were treated for 5 days by intraperitoneal injection of either vehicle, 30 mg/kg perifosine, 40 mg/kg CCI-779, or a combination of both 30 mg/kg perifosine and 40 mg/kg CCI-779. This evidence concerns the gene PTEN and central nervous system cancer.