MAP3K8 and Alzheimer disease: It should be noted the induction of transcriptional activity of the PSA enhancer/promoter cis-regulatory region by TPL2 overexpression in AD-LNCaP cells was more striking (greater than 20 fold) at low levels (0.1∼0.001 nM) of R1881, which is comparable to the physiological levels of androgen in patients who have undergone castration surgery (Figure 1C).